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KMID : 0980720210400010026
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Keimyung Medical Journal
2021 Volume.40 No. 1 p.26 ~ p.31
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Clinically Significant Monocyte Biomarker for Differential Diagnosis of COVID-19 Pneumonia in the Emergency Department
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Kim Hyo-Won
Jeon Jae-Cheon
Choi Woo-Ik
Lee Ji-Yeon
Kwon Yong-Sik
Lee Mi-Jin
Cho Jae-Wan
Kim Gyun-Moo
Mun You-Ho
Lee Sang-Hun
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Abstract
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To determine basic patient characteristics and biomarkers to help in the early diagnosis of Coronavirus disease 2019 (COVID-19) pneumonia in patients with pneumonia who visited the emergency department (ED). This retrospective study evaluated patients diagnosed with community-acquired pneumonia (CAP) or COVID-19 pneumonia in the ED at four tertiary medical centers between February 1 and March 31, 2020. Parameters related to the differential diagnosis between CAP and COVID-19 were investigated. Clinical characteristics and laboratory results of biomarkers were analyzed. In total, 81 patients presented to the ED with COVID-19 pneumonia. Multivariate logistic regression analysis showed that monocyte count [odds ratio (OR): 0.996; 95% confidence interval (CI): 0.994?0.999] and pneumonia severity index (PSI) [OR: 1.025; 95% CI: 1.002?1.049] were associated with diagnosis of COVID-19 pneumonia. The area under the curve comprising the combination of monocyte and PSI was 0.789. Differential diagnosis of COVID-19 pneumonia from pneumonia patients who visited the ED can be made by monocyte count and PSI score.
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KEYWORD
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COVID-19, Emergencies, Monocytes, Pneumonia
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